Interferon-alpha combined with radiotherapy in the treatment of unresectable melanoma

Cancer Invest. 2001;19(3):261-5. doi: 10.1081/cnv-100102553.

Abstract

A case of recurrent and twice resected sinonasal melanoma is presented. The large recurrent tumor was found to regress by a concurrent combination of 6660 cGy photon radiation and subcutaneous interferon-alpha injections given for a period of 8 weeks. Possible mechanisms of potentiation between interferon and radiation are discussed. The unexpected result in this case report raises interesting questions about this treatment combination.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Combined Modality Therapy
  • Humans
  • Interferon-alpha / therapeutic use*
  • Magnetic Resonance Imaging
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology
  • Melanoma / radiotherapy*
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / radiotherapy
  • Paranasal Sinus Neoplasms / drug therapy*
  • Paranasal Sinus Neoplasms / pathology
  • Paranasal Sinus Neoplasms / radiotherapy*
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Interferon-alpha