The isoprostane 8-iso-PGF(2alpha) stimulates endothelial cells to bind monocytes: differences from thromboxane-mediated endothelial activation

FASEB J. 2001 May;15(7):1254-6. doi: 10.1096/fj.00-0498fje.
No abstract available

MeSH terms

  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
  • Cell Adhesion / physiology*
  • Cells, Cultured
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dinoprost / analogs & derivatives
  • Dinoprost / pharmacology*
  • E-Selectin / metabolism
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism*
  • F2-Isoprostanes
  • Humans
  • MAP Kinase Signaling System / physiology
  • Models, Biological
  • Monocytes / metabolism*
  • NF-kappa B / metabolism
  • Protein Kinase C / metabolism
  • Receptors, Thromboxane / antagonists & inhibitors
  • Thromboxanes / metabolism
  • Vascular Cell Adhesion Molecule-1 / metabolism
  • Vasoconstrictor Agents / pharmacology*

Substances

  • E-Selectin
  • F2-Isoprostanes
  • NF-kappa B
  • Receptors, Thromboxane
  • Thromboxanes
  • Vascular Cell Adhesion Molecule-1
  • Vasoconstrictor Agents
  • 8-epi-prostaglandin F2alpha
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • Dinoprost
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C