Abstract
The fractionation of Eugenia caryophyllata (Myrtaceae) guided by the syncytia formation inhibition assay led to the isolation of four tannins (eugeniin, casuarictin, 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose, and tellimagrandin I), and two chromones (biflorin and isobiflorin). Among the isolated compounds, tellimagrandin (4) showed a significantly high inhibitory activity on the syncytia formation with an IC50 value of 16.12 +/- 1.98 micrograms/ml.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromones / chemistry
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Chromones / isolation & purification*
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Chromones / pharmacology
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Giant Cells / drug effects*
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Giant Cells / metabolism
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HIV Envelope Protein gp120 / drug effects
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HIV-1 / drug effects*
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Membrane Fusion / drug effects
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Plant Extracts / chemistry
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Plant Shoots / chemistry
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Rosales / chemistry*
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Tannins / chemistry
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Tannins / isolation & purification*
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Tannins / pharmacology
Substances
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Chromones
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HIV Envelope Protein gp120
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Plant Extracts
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Tannins