Structure-based design of non-peptide HIV protease inhibitors

Farmaco. 2001 Jan-Feb;56(1-2):29-32. doi: 10.1016/s0014-827x(01)01025-4.

Abstract

A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Drug Design*
  • HIV Protease Inhibitors / chemical synthesis
  • HIV Protease Inhibitors / chemistry
  • HIV Protease Inhibitors / pharmacology*
  • Structure-Activity Relationship

Substances

  • HIV Protease Inhibitors