Exploiting site-site interactions on solid support to generate dimeric molecules

Org Lett. 2001 Apr 19;3(8):1185-8. doi: 10.1021/ol015647i.

Authors

H E Blackwell¹, P A Clemons, S L Schreiber

Affiliation

¹ Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 11348190
DOI: 10.1021/ol015647i

Abstract

[structure: see text]. "Intra-site" olefin cross-metathesis on solid support leads to nearly quantitative yields of dimeric molecules.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Binding Sites
Chemistry, Organic / methods*
Chromatography, High Pressure Liquid
Dimerization*
Models, Chemical
Protein Binding
Signal Transduction

Grants and funding

GM-52067/GM/NIGMS NIH HHS/United States