A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L

Org Lett. 2001 May 3;3(9):1307-9. doi: 10.1021/ol0156648.

Abstract

[structure in text] From the leaves of Morinda citrifolia, a new unusual iridoid, named citrifolinoside (1), showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, has been isolated. Its structure was elucidated on the basis of detailed high-field 1D and 2D spectral analysis.

Publication types

  • Comparative Study

MeSH terms

  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Glucosides / therapeutic use*
  • Iridoid Glucosides
  • Iridoids
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phytotherapy*
  • Plants, Medicinal / chemistry
  • Plants, Medicinal / therapeutic use*
  • Rubiaceae / chemistry
  • Rubiaceae / therapeutic use*
  • Skin Neoplasms / drug therapy*
  • Structure-Activity Relationship
  • Transcription Factor AP-1 / antagonists & inhibitors*
  • Transcription Factor AP-1 / metabolism
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / metabolism
  • Ultraviolet Rays / adverse effects*

Substances

  • Glucosides
  • Iridoid Glucosides
  • Iridoids
  • Transcription Factor AP-1
  • citrifolinoside