Abstract
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion. Here we described a member of the gene family found in P. falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Adhesion
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Chromosomes
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Frameshift Mutation
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Genes, Protozoan / genetics*
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Molecular Sequence Data
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Plasmodium falciparum / genetics*
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Plasmodium falciparum / growth & development
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Plasmodium vivax / genetics
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Plasmodium yoelii / genetics
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Protein Biosynthesis*
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Protozoan Proteins / genetics*
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Protozoan Proteins / metabolism*
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Sequence Analysis, DNA
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Sequence Homology
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Transcription, Genetic*