Abstract
Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyltransferases*
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Animals
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Antigens, Bacterial / administration & dosage
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Antigens, Bacterial / immunology
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Bacterial Proteins / administration & dosage
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Bacterial Proteins / immunology*
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Immunization, Secondary*
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Mice
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Mice, Inbred C57BL
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Mycobacterium bovis / immunology*
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Mycobacterium tuberculosis / immunology
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Tuberculosis / immunology
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Tuberculosis / prevention & control*
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Vaccines, DNA / administration & dosage
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Vaccines, DNA / immunology*
Substances
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Antigens, Bacterial
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Bacterial Proteins
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Vaccines, DNA
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Acyltransferases
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antigen 85B, Mycobacterium tuberculosis