Abstract
Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetyl Coenzyme A / metabolism
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Animals
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Biological Transport
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Carnitine O-Palmitoyltransferase / chemistry
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Carnitine O-Palmitoyltransferase / genetics
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Carnitine O-Palmitoyltransferase / metabolism*
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Humans
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Isoenzymes / chemistry
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Kinetics
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Malonyl Coenzyme A / metabolism
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Mitochondria, Heart / enzymology
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Mitochondria, Heart / metabolism
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Myocardium / cytology
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Myocardium / enzymology*
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Myocardium / metabolism*
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Oxidation-Reduction
Substances
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Isoenzymes
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Malonyl Coenzyme A
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Acetyl Coenzyme A
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Carnitine O-Palmitoyltransferase