Objective: To assess the efficacy of chlorophyll derivative (CPD4)-Photodynamic therapy (PDT) in preventing postoperative recurrence of the infiltrative cancer of the urinary bladder.
Methods: Thirty-two patients were treated with CPD4-PDT postoperationally to prevent the recurrence of cancer, all of which being followed up.
Results: The recurrence rate was 42.1% in T2 tumors and 69.2% in T3 tumors (P < 0.05), and the survival period without tumor has been 19.8 +/- 14.8 months in T2 tumors, and 22.67 +/- 19.72 months in T3 tumors (P > 0.05). There was very significant difference in recurrent rate between grade I and grade II, III patients (0 and 66.7%, P < 0.001).
Conclusion: CPD4-PDT is a safe and effective measure to prevent the recurrence in infiltrative bladder cancer after operation.