The induction of donor antigen specific T cell tolerance will be one of the effective treatment for overcoming rejection and improving the alive quality of long-term recipients. It is increasingly noted that dendritic cell may play a two way regulation role in the balance between transplantation rejection and tolerance as the advances of knowledge of dentritic cell maturation stages. This review will focus on the recent advances in the relation between dendritic cell and induction of donor antigen specific tolerance; its mechanism and potential therapeutic application in transplantation.