Objective: To observe the clinical effect of Tongmai Jiangzhi Oral Liquid (TJOL) on blood lipid, lipid peroxidation, prostaglandin metabolism in treating coronary heart disease and angina pectoris with hyperlipidemia.
Methods: Forty-one cases in treated group and 24 in control group were treated with TJOL and Capsulae Oenoth Erae Biennisolei (COEB) for one month respectively. Serum lipid, apolipoprotein, plasma malonyldialdehyde (MDA), superoxide dismutase (SOD), thromboxane B2(TXB2), 6-keto-prostaglandin F1 alpha and blood glutathione peroxidase (GSH-Px) were measured before and after treatment.
Results: After treatment with TJOL, the total effective rate was 87.80% in relieving angina and 50.00% in improving ECG. Other data showed that the levels of serum TC, TG, apoB, plasma MDA, TXB2 and TXB2/6-keto-prostaglandin F1 alpha ratio lowered and levels of apoA, GSH-Px, serum HDL-C, apoA1/apoB increased (P < 0.05-P < 0.001).
Conclusions: TJOL could effectively lower blood lipid, reduce injury caused by free radicals, regulate prostaglandin metabolism and treat coronary heart disease. By this study, an effective prescription of Chinese herbal medicine was offered for prevention and treatment of coronary heart disease.