Sudden cardiac death, genes, and arrhythmogenesis: consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, Part II

P M Spooner; C Albert; E J Benjamin; R Boineau; R C Elston; A L George Jr; X Jouven; L H Kuller; J W MacCluer; E Marbán; J E Muller; P J Schwartz; D S Siscovick; R P Tracy; W Zareba; D P Zipes

doi:10.1161/01.cir.103.20.2447

Sudden cardiac death, genes, and arrhythmogenesis: consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, Part II

Circulation. 2001 May 22;103(20):2447-52. doi: 10.1161/01.cir.103.20.2447.

Authors

P M Spooner¹, C Albert, E J Benjamin, R Boineau, R C Elston, A L George Jr, X Jouven, L H Kuller, J W MacCluer, E Marbán, J E Muller, P J Schwartz, D S Siscovick, R P Tracy, W Zareba, D P Zipes

Affiliation

¹ National Heart, Lung, and Blood Institute, Bethesda, MD 20892-7940, USA. [email protected]

PMID: 11369684
DOI: 10.1161/01.cir.103.20.2447

Abstract

This is Part II of a 2-part article dealing with malignant ventricular arrhythmias, which are the leading mechanism of death in common cardiac diseases. Genetic population studies directed at discovering common proximal sources of inherited molecular risk most directly linked to arrhythmia initiation and propagation would appear to have considerable potential in helping reduce cardiovascular mortality.

Publication types

Congress

MeSH terms

Arrhythmias, Cardiac / complications
Arrhythmias, Cardiac / genetics*
Death, Sudden, Cardiac / etiology*
Genetic Predisposition to Disease
Humans
Mutation
Myocardial Infarction / complications
Myocardial Infarction / genetics
National Institutes of Health (U.S.)
Phenotype
Risk Factors
United States