Abstract
Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.
MeSH terms
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology*
-
Anti-Inflammatory Agents / pharmacology
-
China
-
Cytokines / biosynthesis
-
Humans
-
Immunosuppressive Agents / isolation & purification
-
Immunosuppressive Agents / pharmacology*
-
Magnetic Resonance Spectroscopy
-
Monocytes / drug effects
-
Monocytes / metabolism
-
Plants, Medicinal / chemistry*
-
Prednisolone / pharmacology
-
Sesquiterpenes / isolation & purification
-
Sesquiterpenes / pharmacology*
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Infrared
Substances
-
Alkaloids
-
Anti-Inflammatory Agents
-
Cytokines
-
Immunosuppressive Agents
-
Sesquiterpenes
-
Prednisolone