Abstract
An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
MeSH terms
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Adult
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Aged
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Clinical Trials as Topic
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Dopamine Agonists / administration & dosage*
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Dopamine Agonists / adverse effects
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Dose-Response Relationship, Drug
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Patient Satisfaction
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Pergolide / administration & dosage*
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Pergolide / adverse effects
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Polysomnography / drug effects
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Restless Legs Syndrome / drug therapy*
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Restless Legs Syndrome / physiopathology
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Sleep / drug effects
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Sleep / physiology
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Time Factors
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Treatment Outcome
Substances
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Dopamine Agonists
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Pergolide