Biomarker studies on gold-lined sea bream (Rhabdosargus sarba) exposed to benzo[a]pyrene

Water Sci Technol. 2001;43(2):155-60.

Abstract

Gold-lined sea bream (Rhabdosargus sarba) were intraperitoneally injected with 35 mg/kg benzo[a]pyrene (in DMSO), with fish administered DMSO as the solvent control. Fish were sacrificed 3 days post injection and their livers dissected for the analysis of adenosine triphosphates (ATPase), glutathione-S-transferase (GST), DNA adducts and ethyoxyresorufin-O-deethylase (EROD). Exposure to B[a]P resulted in reduced ATPase activity, elevated GST activity and DNA adduct level, but no apparent change in EROD activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Animals
  • Benzo(a)pyrene / adverse effects*
  • Biomarkers / analysis
  • Carcinogens / adverse effects*
  • Cytochrome P-450 CYP1A1 / metabolism
  • DNA Adducts
  • Fishes / physiology*
  • Glutathione Transferase / metabolism
  • Liver / drug effects
  • Liver / enzymology

Substances

  • Biomarkers
  • Carcinogens
  • DNA Adducts
  • Benzo(a)pyrene
  • Cytochrome P-450 CYP1A1
  • Glutathione Transferase
  • Adenosine Triphosphatases