Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia

H Starke; M Raida; V Trifonov; J H Clement; I F Loncarevic; A Heller; C Bleck; A Nietzel; N Rubtsov; U Claussen; T Liehr

doi:10.1046/j.1365-2141.2001.02787.x

Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia

Br J Haematol. 2001 May;113(2):435-8. doi: 10.1046/j.1365-2141.2001.02787.x.

Authors

H Starke¹, M Raida, V Trifonov, J H Clement, I F Loncarevic, A Heller, C Bleck, A Nietzel, N Rubtsov, U Claussen, T Liehr

Affiliation

¹ Institute of Human Genetics and Anthropology, Friedrich Schiller University, Jena, Germany.

PMID: 11380412
DOI: 10.1046/j.1365-2141.2001.02787.x

Abstract

A case of chronic myelogenous leukaemia (CML) in a 48-year-old man is reported. To the best of our knowledge, this is the first report of a Philadelphia-negative CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole abnormality. The derivative chromosome 11 was studied in detail using molecular cytogenetic methods; fluorescence in situ hybridization (FISH) using centromere- and region-specific probes for chromosome 11, microdissection, micro-comparative genomic hybridization (micro-CGH) and the recently developed multicolour banding (MCB) technique. The acquired SMC was determined to be a ring chromosome that can be described as r(11)(:p11.2-->q13.1:q14:).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Aberrations / genetics*
Chromosome Disorders
Chromosomes, Human, Pair 11*
Genetic Markers
Humans
Image Processing, Computer-Assisted
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics*
Male
Middle Aged

Substances

Genetic Markers