Abstract
Hepatic adverse effects occur very rarely with alpha-interferon therapy. A case of acute hepatitis induced by alpha-interferon in a 33-year-old man with chronic hepatitis C is described. The patient developed acute hepatitis with very high aminotransferase activity and jaundice. After discontinuing alpha-interferon therapy, hepatitis resolved rapidly. The immune-mediated mechanism is the most probable cause of this hepatitis.
MeSH terms
-
Acute Disease
-
Adult
-
Alanine Transaminase / blood
-
Antiviral Agents / adverse effects*
-
Aspartate Aminotransferases / blood
-
Chemical and Drug Induced Liver Injury / etiology*
-
Chemical and Drug Induced Liver Injury / immunology
-
Chemical and Drug Induced Liver Injury / metabolism
-
Hepatitis C, Chronic / therapy*
-
Humans
-
Immunologic Factors / adverse effects*
-
Interferon-alpha / adverse effects*
-
Jaundice / chemically induced
-
Jaundice / metabolism
-
Male
Substances
-
Antiviral Agents
-
Immunologic Factors
-
Interferon-alpha
-
Aspartate Aminotransferases
-
Alanine Transaminase