Lymphocyte diversity in a 9-year-old boy with idiopathic CD4+ T cell lymphocytopenia

M Frühwirth; K Clodi; A Heitger; N Neu

doi:10.1159/000053800

Lymphocyte diversity in a 9-year-old boy with idiopathic CD4+ T cell lymphocytopenia

Int Arch Allergy Immunol. 2001 May;125(1):80-5. doi: 10.1159/000053800.

Authors

M Frühwirth¹, K Clodi, A Heitger, N Neu

Affiliation

¹ Department of Pediatrics, University of Innsbruck, School of Medicine, Innsbruck, Austria.

PMID: 11385292
DOI: 10.1159/000053800

Abstract

Since CD4+ lymphocytopenia can be caused by disturbed thymic T-cell maturation, we investigated the T-cell subsets of a 9-year-old boy fulfilling the diagnostic criteria for CD4+ lymphocytopenia in a follow-up period of 4 years. We found (I) reduced CD45RA expression, (II) enhanced CD45RO expression and (III) a significant increase in gamma delta TCR-bearing T cells. An accelerated apoptosis (11%) was observed in the CD45RO+, but not CD45RA+ subset. These findings provide evidence that a disturbed thymic T-cell maturation process might play a role in the pathogenesis of CD4+ lymphocytopenia.

Publication types

Case Reports

MeSH terms

Apoptosis
Child
Follow-Up Studies
Humans
Leukocyte Common Antigens / analysis
Male
Receptors, Antigen, T-Cell, gamma-delta / analysis
T-Lymphocyte Subsets / immunology*
T-Lymphocytopenia, Idiopathic CD4-Positive / immunology*

Substances

Receptors, Antigen, T-Cell, gamma-delta
Leukocyte Common Antigens