Progress toward the total synthesis of ingenol: construction of the complete carbocyclic skeleton

H Tang; N Yusuff; J L Wood

doi:10.1021/ol015855a

Progress toward the total synthesis of ingenol: construction of the complete carbocyclic skeleton

Org Lett. 2001 May 17;3(10):1563-6. doi: 10.1021/ol015855a.

Authors

H Tang¹, N Yusuff, J L Wood

Affiliation

¹ Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

PMID: 11388867
DOI: 10.1021/ol015855a

Abstract

[reaction: see text] The complete carbocyclic skeleton of ingenol is assembled via a route that employs ring-closing metathesis (RCM) to close the strained "inside-outside" BC ring system (i.e., 24 --> 25).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis
Antineoplastic Agents / chemical synthesis
Diterpenes / chemical synthesis*
Irritants / chemical synthesis*

Substances

Anti-HIV Agents
Antineoplastic Agents
Diterpenes
Irritants
ingenol