Duration of neuronal stretch correlates with functional loss

Otolaryngol Head Neck Surg. 2001 Jun;124(6):641-4. doi: 10.1177/019459980112400608.

Abstract

Postoperative cranial nerve weakness or paralysis is not uncommon in many otolaryngologic surgical procedures. Our study used a rat model to test the hypothesis that the length of time that a nerve is under tension may be an important variable in the amount of postoperative paresis. Forty Sprague-Dawley rats were divided into 4 groups that underwent either a sham operation or a traction injury for 1, 2, or 5 minutes. The traction injury was performed with a vessel loop placed around the sciatic nerve with 50 g of tension. Traction injury for 1 or 2 minutes did not result in any statistical differences in the motor capabilities of the lower limb. However, those animals with a stretch injury for 5 minutes had a significant loss of function (P < 0.01) when compared with all other groups. Histologic examination of nerves harvested on postoperative day 7 showed no evidence of mechanical injury. This study demonstrates that even minimal tension, if maintained for a significant amount of time, may result in postoperative weakness.

MeSH terms

  • Animals
  • Cranial Nerve Injuries / etiology*
  • Male
  • Otorhinolaryngologic Surgical Procedures / adverse effects*
  • Paresis / etiology*
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors