[Malignant tumors in patients with kidney transplants]

Urologiia. 2000 Sep-Oct:(5):11-5.
[Article in Russian]

Abstract

In this retrospective study we evaluated incidence of malignancies observed among 718 renal transplant recipients with at least 6 months of follow-up. A total of 461 men and 257 women (mean age at transplantation 36.3 +/- 8.3 years) were included. Thirty three out of 718 recipients (4.6%) developed malignant neoplasia: 45.4% of these were Kaposi's sarcomas, 12.1%--cancers of the uterine cervix, 12.1% cancers of the stomach, 12.1%--basal cell carcinomas, 6.06%--posttransplant lymphoproliferative disorder. There was no significant effect of either cyclosporin A doses or OKT3/ATG on the incidence of the tumors. Mean age of transplant recipients with malignancies was statistically higher as compared to those without malignancies (45.5 +/- 8.2 years versus 36.1 +/- 8.4 years, p < 0.00001). The median time from onset of end-stage renal failure (dialysis start) and from the transplantation to the diagnosis of the tumor make up 32 (16-161) and 23 (5-158) months, respectively. One renal transplant patient suffered from multiple myeloma with aggressive course.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Carcinoma, Basal Cell / epidemiology
  • Female
  • Humans
  • Incidence
  • Kidney Transplantation* / adverse effects
  • Kidney Transplantation* / pathology
  • Liver / diagnostic imaging
  • Liver / pathology
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / pathology
  • Male
  • Middle Aged
  • Multiple Myeloma / epidemiology
  • Neoplasms / epidemiology*
  • Retrospective Studies
  • Risk Factors
  • Sarcoma, Kaposi / epidemiology
  • Sex Factors
  • Skin Neoplasms / epidemiology
  • Stomach Neoplasms / epidemiology
  • Tomography, X-Ray Computed
  • Uterine Cervical Neoplasms / epidemiology