Abstract
Authors have studied the antimutagenic power of alphahederin (a saponin extracted from Hedera helix) versus a clastogenic agent, doxorubicin and an aneugenic agent, carbendazim. We have applied a protocol of incorporation of alphahederin (pretreatment, simultaneous treatment and post treatment) to determine a mechanism of action. According to this protocol, alphahederin induces a significant diminution of the rate of micronuclei wathever the phases of the protocol. These results demonstrate the antimutagenic activity of alphahederin with a mechanism of action, both desmutagenic and bioantimutagenic.
MeSH terms
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Air Pollutants, Occupational / toxicity
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Antifungal Agents / pharmacology*
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Antimutagenic Agents*
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Benzimidazoles / toxicity
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Carbamates*
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Cells, Cultured
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Cytochalasin B / pharmacology
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Doxorubicin / toxicity
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Humans
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Lymphocytes / cytology
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Lymphocytes / drug effects*
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Micronucleus Tests*
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Mutagens / toxicity*
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Oleanolic Acid* / analogs & derivatives*
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Plant Extracts
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Saponins / pharmacology*
Substances
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Air Pollutants, Occupational
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Antifungal Agents
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Antimutagenic Agents
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Benzimidazoles
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Carbamates
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Mutagens
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Plant Extracts
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Saponins
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beta-hederin
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Cytochalasin B
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Oleanolic Acid
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Doxorubicin
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carbendazim