Abstract
We used a gentamicin protection assay to assess the ability of gestational pyelonephritis isolates of Escherichia coli to invade HeLa cells. The ability to enter HeLa cells was strongly associated with the presence of Dr operons coding for Dr adhesins. In contrast, the nonivasive isolates predominantly expressed papG, coding for P fimbriae.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adhesins, Bacterial / genetics
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Adhesins, Bacterial / metabolism
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Adhesins, Bacterial / physiology*
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CD55 Antigens / metabolism
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Escherichia coli / pathogenicity*
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Female
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Fimbriae, Bacterial / genetics
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Fimbriae, Bacterial / metabolism
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HeLa Cells
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Humans
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Operon*
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Pregnancy
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Pregnancy Complications, Infectious / microbiology*
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Pyelonephritis / microbiology*
Substances
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Adhesins, Bacterial
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CD55 Antigens