[Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors]

Ter Arkh. 2001;73(3):33-7.
[Article in Russian]

Abstract

Aim: To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development.

Material and methods: 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis.

Results: An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD.

Conclusion: Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Bronchitis / complications*
  • Bronchitis / diagnosis
  • Bronchitis / genetics
  • Bronchitis / prevention & control
  • Chronic Disease
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Lung Diseases, Obstructive / diagnosis
  • Lung Diseases, Obstructive / etiology*
  • Lung Diseases, Obstructive / genetics
  • Lung Diseases, Obstructive / prevention & control
  • Male
  • Middle Aged
  • Models, Theoretical
  • Multivariate Analysis
  • Prognosis

Substances

  • Genetic Markers