Abstract
Liver penetration is a rare but serious complication of peptic ulcer disease. We report a case of a 33-year-old woman who took large doses of nonsteroidal antiinflammatory drugs and developed a giant duodenal ulcer that penetrated into her liver. The diagnosis was based on histologic examination of endoscopic biopsies. She was initially treated with a proton pump inhibitor, but, within 5 weeks, she developed a symptomatic postbulbar stricture that required surgical correction. We also review 11 other reported cases of endoscopically and histologically diagnosed peptic ulcer penetration into the liver.
MeSH terms
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Chemical and Drug Induced Liver Injury*
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Diclofenac / administration & dosage
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Diclofenac / adverse effects*
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Duodenal Ulcer / chemically induced*
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Duodenal Ulcer / pathology
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Duodenal Ulcer / surgery
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Duodenoscopy
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Duodenum / pathology
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Female
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Humans
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Immunoenzyme Techniques
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Intervertebral Disc Displacement / drug therapy*
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Keratins / analysis
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Liver / pathology
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Liver Diseases / pathology
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Liver Diseases / surgery
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Liver Function Tests
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Peptic Ulcer Hemorrhage / chemically induced
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Peptic Ulcer Hemorrhage / pathology
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Peptic Ulcer Hemorrhage / surgery
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Peptic Ulcer Perforation / chemically induced*
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Peptic Ulcer Perforation / pathology
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Peptic Ulcer Perforation / surgery
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Diclofenac
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Keratins