Abstract
54 patients with advanced malignancy refractory to chemotherapy were studied to evaluate efficacy and toxicity of continuous infusion of 5-fluorouracil (5FU) given for 3 weeks. We report results of the first 156 courses given in combination with other drugs. 19 (37%) of the 54 responded, including 3 (6%) with complete response. Toxicity was acceptable, with mucositis in 13 (26%) and 3 (6%) with grade II-III toxicity. Results and toxicity profile were compatible with further disease-oriented studies using this dose-intensive program.
Publication types
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Clinical Trial
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English Abstract
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antimetabolites, Antineoplastic / administration & dosage*
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Antimetabolites, Antineoplastic / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Carboplatin / therapeutic use
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Cisplatin / administration & dosage
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Dose-Response Relationship, Drug
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Female
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Fluorouracil / administration & dosage*
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Fluorouracil / adverse effects
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Humans
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Infusions, Intravenous
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Male
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Middle Aged
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Mitomycin / therapeutic use
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Neoplasms / drug therapy*
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Time Factors
Substances
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Antimetabolites, Antineoplastic
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Bleomycin
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Mitomycin
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Carboplatin
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Cisplatin
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Fluorouracil