Abstract
Several 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives were synthesized and tested for their ability to inhibit human platelet aggregation in vitro induced by arachidonic acid, collagen and ADP. Only five compounds showed any appreciable activity, and the results of all the active derivatives were similar to those of papaverine in the test with arachidonic acid and collagen. Moreover, the most active compounds were investigated in the test with ADP and again showed a significant activity. The tested compounds that possessed the best activity were also shown to increase the c-AMP level significantly without involving the adenylyl cyclase system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Diphosphate / antagonists & inhibitors
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Adenosine Diphosphate / pharmacology
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Arachidonic Acid / antagonists & inhibitors
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Arachidonic Acid / pharmacology
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Blood Platelets / drug effects*
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Blood Platelets / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Collagen / antagonists & inhibitors
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Collagen / pharmacology
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Cyclic AMP / blood
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Humans
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In Vitro Techniques
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Naphthyridines / chemical synthesis*
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Naphthyridines / pharmacology
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemical synthesis*
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Platelet Aggregation Inhibitors / pharmacology*
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Indicators and Reagents
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Naphthyridines
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Platelet Aggregation Inhibitors
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Arachidonic Acid
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Adenosine Diphosphate
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Collagen
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Cyclic AMP