Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family

K F Leung; W Y Au; A Y Chan; L C Chan; J S Waye; D H Chui; S K Ma

doi:10.1046/j.1365-2257.2001.00349.x

Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family

Clin Lab Haematol. 2001 Feb;23(1):53-5. doi: 10.1046/j.1365-2257.2001.00349.x.

Authors

K F Leung¹, W Y Au, A Y Chan, L C Chan, J S Waye, D H Chui, S K Ma

Affiliation

¹ Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China.

PMID: 11422231
DOI: 10.1046/j.1365-2257.2001.00349.x

Abstract

A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.

Publication types

Case Reports

MeSH terms

Adult
Anemia, Hemolytic, Congenital / etiology
Anemia, Hemolytic, Congenital / genetics
China
Family Health
Female
Genotype
Hemoglobins, Abnormal / genetics*
Heterozygote
Humans
Nuclear Family
Osmotic Fragility / genetics
Pedigree
Phenotype
Spherocytosis, Hereditary / blood
Spherocytosis, Hereditary / complications
Spherocytosis, Hereditary / genetics*

Substances

Hemoglobins, Abnormal
hemoglobin Q Thailand