Variable sequences in the long terminal repeat and Its downstream region of some of HIV Type 1 CRF01_AE recently distributing among Thai carriers

AIDS Res Hum Retroviruses. 2001 Jun 10;17(9):863-6. doi: 10.1089/088922201750252061.

Abstract

Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in and downstream of the 5' long terminal repeat (LTR) were compared among samples obtained from 13 HIV-1 CRF01_AE-infected individuals in Thailand from 1998 to 1999. Eleven individuals had highly conserved sequences compared with previously reported CRF01_AE viruses. However, T cell-specific factor (TCF)-1alpha motif, which is located just beside the 3' terminus of the nef sequence, was duplicated in 2 out of the 13 subjects, one of whom had also lost the 24 nucleotides next to the 3' of the primer-binding site. Thus, several characteristics of CRF01_AE LTR and gag-leader sequence were identified in some samples recently obtained in Thailand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA, Viral
  • Genetic Variation*
  • HIV Enhancer
  • HIV Infections / blood
  • HIV Infections / virology*
  • HIV Long Terminal Repeat*
  • HIV-1 / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Thailand

Substances

  • DNA, Viral

Associated data

  • GENBANK/AB052600
  • GENBANK/AB052601
  • GENBANK/AB052602
  • GENBANK/AB052603
  • GENBANK/AB052604
  • GENBANK/AB052605
  • GENBANK/AB052606
  • GENBANK/AB052607
  • GENBANK/AB052608
  • GENBANK/AB052609
  • GENBANK/AB052610
  • GENBANK/AB052611
  • GENBANK/AB052612