Vertilecanins: new phenopicolinic acid analogues from Verticillium lecanii

A G Soman; J B Gloer; R F Angawi; D T Wicklow; P F Dowd

doi:10.1021/np000094q

Vertilecanins: new phenopicolinic acid analogues from Verticillium lecanii

J Nat Prod. 2001 Feb;64(2):189-92. doi: 10.1021/np000094q.

Authors

A G Soman¹, J B Gloer, R F Angawi, D T Wicklow, P F Dowd

Affiliation

¹ Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.

PMID: 11429997
DOI: 10.1021/np000094q

Abstract

Five new phenopicolinic acid analogues (1-5) have been isolated from solid-substrate fermentation cultures of Verticillium lecanii. The most abundant component (vertilecanin A; 1) displays antiinsectan activity against Helicoverpa zea. These compounds were obtained by chromatographic fractionation of the EtOAc culture extract and identified by analysis of NMR and MS data. The known fungal metabolites 2-decenedioic acid and 10-hydroxy-8-decenoic acid were also isolated from these cultures.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amanita / chemistry
Fatty Acids, Monounsaturated / isolation & purification
Fermentation
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Chemical
Picolinic Acids / chemistry
Picolinic Acids / isolation & purification*
Verticillium / chemistry*

Substances

Fatty Acids, Monounsaturated
Picolinic Acids
vertilecanin A
vertilecanin B
vertilecanin C
10-hydroxy-8-decenoic acid