Abstract
[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Diterpenes / chemical synthesis*
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Diterpenes / chemistry
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Diterpenes / pharmacology
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Fermentation
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Hypocreales / growth & development
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Immunosuppressive Agents / chemical synthesis
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Kv1.1 Potassium Channel
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Potassium Channel Blockers*
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Potassium Channels*
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Potassium Channels, Voltage-Gated*
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Pyrones / pharmacology
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Recombinant Proteins / antagonists & inhibitors
Substances
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Diterpenes
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Immunosuppressive Agents
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Potassium Channel Blockers
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Potassium Channels
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Potassium Channels, Voltage-Gated
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Pyrones
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Recombinant Proteins
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candelalide A
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candelalide B
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candelalide C
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Kv1.1 Potassium Channel