Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi

N K Utkina; V A Denisenko; O V Scholokova; M V Virovaya; A V Gerasimenko; D Y Popov; V B Krasokhin; A M Popov

doi:10.1021/np0003544

Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi

J Nat Prod. 2001 Feb;64(2):151-3. doi: 10.1021/np0003544.

Authors

N K Utkina¹, V A Denisenko, O V Scholokova, M V Virovaya, A V Gerasimenko, D Y Popov, V B Krasokhin, A M Popov

Affiliation

¹ Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 690022 Vladivostok, Russia. [email protected]

PMID: 11434317
DOI: 10.1021/np0003544

Abstract

Two new cytotoxic tetrabromodibenzo-p-dioxins, spongiadioxins A (1) and B (2), were isolated from an Australian marine sponge Dysidea dendyi. The structures of these compounds were established by 1D and 2D NMR spectroscopy, X-ray analysis of the methyl ether of spongiadioxin A (3), and synthesis of the methyl ether of spongiadioxin B (4) from diphenyl ether (9) isolated from Dysidea herbacea.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Australia
Dioxins / chemistry
Dioxins / isolation & purification*
Dioxins / pharmacology
Magnetic Resonance Spectroscopy
Models, Chemical
Models, Molecular
Porifera / chemistry*

Substances

Dioxins
spongiadioxin A
spongiadioxin B