Abstract
The yeast ubiquitin fusion degradation 1 (Ufd1) protein is involved in a degradation pathway for ubiquitin fused products. The human ortholog gene (UFD1-like, UFD1L) is deleted in patients affected by the DiGeorge/velocardiofacial syndromes. We report the cloning of UFD1L orthologs from Drosophila melanogaster (dufd1l), Xenopus laevis and Gallus gallus. The 1,125-bp Drosophila cDNA encodes a protein of 316 amino acids, showing 60% identity with the human and murine proteins. The identity to the G. gallus, X. laevis, C. elegans and S. cerevisiae proteins is 95%, 83%, 32%, and 36%, respectively. Northern expression data in Drosophila indicate that dufd1l is expressed through embryonic, larval and pupal development, as well as in the adult fly.
Copyright 2001 S. Karger AG, Basel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Aging / genetics
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Amino Acid Sequence
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Animals
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Chickens / genetics*
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Cloning, Molecular
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Conserved Sequence / genetics*
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DNA, Complementary / genetics
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Drosophila melanogaster / embryology
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Drosophila melanogaster / genetics*
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Expressed Sequence Tags
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Gene Expression Regulation, Developmental
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Humans
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Intercellular Signaling Peptides and Proteins
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Intracellular Signaling Peptides and Proteins
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Larva / genetics
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Mice
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Molecular Sequence Data
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Proteins / chemistry
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Proteins / genetics*
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Pupa / genetics
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Sequence Alignment
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Xenopus Proteins*
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Xenopus laevis / genetics*
Substances
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Adaptor Proteins, Vesicular Transport
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DNA, Complementary
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Intercellular Signaling Peptides and Proteins
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Intracellular Signaling Peptides and Proteins
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Proteins
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RNA, Messenger
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UFD1 protein, Xenopus
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UFD1 protein, human
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Ufd1 protein, mouse
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Xenopus Proteins