The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3

Cytogenet Cell Genet. 2001;92(3-4):300-3. doi: 10.1159/000056918.

Abstract

Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Carrier Proteins / genetics*
  • Chromosomes, Human, Pair 4 / genetics*
  • Contig Mapping
  • Exons / genetics*
  • Expressed Sequence Tags
  • Gene Expression Profiling
  • Humans
  • Internet
  • Introns / genetics*
  • Lod Score
  • Membrane Glycoproteins / genetics*
  • Mice
  • Physical Chromosome Mapping*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Radiation Hybrid Mapping
  • Sequence Homology

Substances

  • Carrier Proteins
  • HHIP protein, human
  • Hhip protein, mouse
  • Membrane Glycoproteins
  • RNA, Messenger