Abstract
A 61-year-old man with muscle aches and persistently elevated serum creatine kinase had aggregates of randomly oriented, rhomboidal or rectangular protein crystalline inclusions in the sarcoplasm of type II fibers. Immunochemical studies showed strong reactivity of the inclusions to tubulin antibodies, suggesting that these unique crystalline inclusions may be a consequence of altered synthesis, processing, or degradation of tubulin.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Crystallization
-
Humans
-
Inclusion Bodies / metabolism*
-
Inclusion Bodies / pathology*
-
Male
-
Middle Aged
-
Muscle Fibers, Skeletal / metabolism
-
Muscle Fibers, Skeletal / pathology
-
Muscular Diseases / metabolism*
-
Muscular Diseases / pathology*
-
Sarcoplasmic Reticulum / metabolism
-
Sarcoplasmic Reticulum / pathology
-
Tubulin / chemistry
-
Tubulin / metabolism*