Abstract
An understanding of the antigen presentation mechanisms that mediate induction of protective immune responses against malaria is essential for the development of successful immunization approaches. Here we show that dendritic cells presenting Plasmodium yoelii sporozoite antigens are able to activate specific CD4(+) and CD8(+) T cells and initiate protective immune responses against malaria in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Protozoan / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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Dendritic Cells / immunology*
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Interferon-gamma / immunology
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Malaria / immunology*
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Malaria / prevention & control
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Plasmodium yoelii / immunology*
Substances
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Antigens, Protozoan
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Interferon-gamma