Abstract
Severe hypotensive reactions that occur during transfusions of blood products to non-transplanted patients were recently linked to the use of bedside leukocyte-reduction filters, sometimes in association with angiotensin-converting enzyme (ACE) inhibitor treatment. We present the first report of such reactions in patients who underwent orthotopic heart transplantation. Fourteen (47%) of the 30 transfused patients experienced severe hypotensive reaction during filtered transfusion of at least 1 unit of blood product, with a total of 24 episodes. Eleven (79%) of these patients were treated pre-operatively with ACE inhibitors.
MeSH terms
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / adverse effects*
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Blood Transfusion / methods*
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Blood Transfusion / statistics & numerical data
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Bradykinin / blood
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Bradykinin / drug effects
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Erythrocyte Transfusion / adverse effects
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Filtration / methods
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Heart Transplantation* / statistics & numerical data
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Humans
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Hypotension / epidemiology*
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Hypotension / etiology*
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Hypotension / therapy
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Incidence
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Leukocyte Transfusion / adverse effects
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Leukocyte Transfusion / methods
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Leukocyte Transfusion / statistics & numerical data
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Platelet Transfusion / adverse effects
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Premedication
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Transfusion Reaction*
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Bradykinin