Abstract
In the search for new chemotherapeutic agents, we have focused our work on the synthesis and the study of several unnatural beta-L-nucleoside analogues. In this paper, we report on the synthesis of beta-L-pentofuranonucleosides (and their 2'-deoxy derivatives) of 5-fluorouracil and their inhibitory effects on the proliferation of several murine and human tumor cells. The corresponding 5-fluorocytosine derivatives were also synthesized and their anti-HIV and anti-HBV activities have been evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Cell Division / drug effects
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Drug Design
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Flucytosine / analogs & derivatives*
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Fluorouracil / analogs & derivatives*
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HIV / drug effects
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Humans
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Mice
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Nucleosides / pharmacology*
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Nucleosides / toxicity
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Stereoisomerism
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Structure-Activity Relationship
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T-Lymphocytes / cytology
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
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Tumor Cells, Cultured
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Nucleosides
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Flucytosine
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Fluorouracil