[I/D polymorphism in the angiotensin-converting enzyme gene in men with myocardial infarction at young age]

O A Berkovich; E A Bazhenova; E A Volkova; M Z Alugishvili; I O Kiselev; B I Smirnov; E I Shvarts; E V Shliakhto

[I/D polymorphism in the angiotensin-converting enzyme gene in men with myocardial infarction at young age]

Ross Fiziol Zh Im I M Sechenova. 2001 May;87(5):642-8.

[Article in Russian]

Authors

O A Berkovich¹, E A Bazhenova, E A Volkova, M Z Alugishvili, I O Kiselev, B I Smirnov, E I Shvarts, E V Shliakhto

Affiliation

¹ St. Petersburg I. P. Pavlov State Medical University, 197022, St. Petersburg, Leo Tolstoy St., 6/8, Russia.

PMID: 11452798

Abstract

The rate of D allele did not differ between patients with ischemic heart disease (IHD) who had myocardial infarction before the age 45, and healthy males. The DD genotype of the ACE gene was much more frequently encountered in the patients than in healthy males. The findings suggest that the DD genotype is an independent risk factor of the IHD and myocardial infarction in young patients.

Publication types

English Abstract

MeSH terms

Adult
Genotype
Humans
Male
Mutagenesis, Insertional
Myocardial Infarction / enzymology*
Myocardial Infarction / mortality
Peptidyl-Dipeptidase A / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Deletion

Substances

Peptidyl-Dipeptidase A