Platelet adhesion to fibrinogen coated at various densities

M Jirousková; B S Coller

doi:10.1111/j.1749-6632.2001.tb03532.x

Platelet adhesion to fibrinogen coated at various densities

Ann N Y Acad Sci. 2001:936:464-5. doi: 10.1111/j.1749-6632.2001.tb03532.x.

Authors

M Jirousková¹, B S Coller

Affiliation

¹ Mount Sinai School of Medicine, Box 1118, One Gustave L. Levy Place, New York, NY 10029, USA. [email protected]

PMID: 11460503
DOI: 10.1111/j.1749-6632.2001.tb03532.x

Abstract

Platelet adhesion to low-density coated fibrinogen induces greater protein tyrosine phosphorylation of SYK and FAK than adhesion to high-density coated fibrinogen, and leads to activation of integrin alpha IIb beta 3 on the luminal side of adherent platelets.

MeSH terms

Blood Platelets / cytology*
Blood Platelets / metabolism
Cell Adhesion*
Fibrinogen / metabolism*
Phosphorylation
Platelet Glycoprotein GPIIb-IIIa Complex / metabolism
Tyrosine / metabolism

Substances

Platelet Glycoprotein GPIIb-IIIa Complex
Tyrosine
Fibrinogen