Cofactors for HIV disease progression in a cohort of homosexual and bisexual men

J Acquir Immune Defic Syndr. 2001 Jul 1;27(3):308-14. doi: 10.1097/00126334-200107010-00015.

Abstract

To evaluate cofactors for progression of HIV infection, the authors identified 370 men with well-defined seroconversion dates and cofactor data among participants in the San Francisco City Clinic Cohort (SFCCC). Postseroconversion substance use, sexual behavior, and sexually transmitted diseases were assessed using multivariate proportional hazards models. Weekly use of hallucinogens strongly and independently predicted death (relative hazard [RH], 2.59; 95% confidence interval [CI], 1.56-4.28), as well as diagnosis of AIDS; weekly cocaine use also predicted mortality. Receptive anal intercourse with ejaculation was independently associated with mortality risk (RH, 1.45; 95% CI, 1.02-2.04) and AIDS. The associations of accelerated progression with weekly use of recreational drugs and unprotected receptive anal intercourse need to be confirmed in other prospective cohorts.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Bisexuality*
  • Cohort Studies
  • Disease Progression
  • HIV Infections / complications
  • HIV Infections / mortality*
  • HIV Seropositivity / complications
  • HIV Seropositivity / diagnosis
  • HIV Seropositivity / mortality
  • Homosexuality, Male*
  • Humans
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Sexual Behavior
  • Sexually Transmitted Diseases / complications*
  • Sexually Transmitted Diseases / mortality
  • Substance-Related Disorders / complications*
  • Substance-Related Disorders / mortality