Abstract
A 19-month-old girl with congenital nephrotic syndrome of the Finnish type underwent a living-related renal transplant; 24 h after transplantation she became massively nephrotic. She did not respond to steroids, plasmapheresis, and high-dose cyclosporine. A month later, a renal biopsy showed only glomerular foot process effacement. She was treated with high-dose methylprednisolone pulses and oral cyclophosphamide. She rapidly went into complete remission with no further relapses. Graft function has been stable 2 years after transplantation.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use
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Child, Preschool
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Cyclophosphamide / adverse effects
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Cyclophosphamide / therapeutic use
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Female
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Humans
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use
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Kidney / pathology
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Kidney Glomerulus / pathology
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Kidney Transplantation / adverse effects*
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Methylprednisolone / adverse effects
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Methylprednisolone / therapeutic use
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Nephrosis / pathology*
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Nephrotic Syndrome / congenital
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Nephrotic Syndrome / surgery*
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Serum Albumin / metabolism
Substances
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Anti-Inflammatory Agents
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Immunosuppressive Agents
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Serum Albumin
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Cyclophosphamide
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Methylprednisolone