Cytokeratin-positive, CD45-negative primary centroblastic lymphoma of the adrenal gland: a potential for a diagnostic pitfall

Arch Pathol Lab Med. 2001 Aug;125(8):1104-6. doi: 10.5858/2001-125-1104-CPCNPC.

Abstract

We report a case of cytokeratin-positive, CD45-negative primary polymorphic centroblastic lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 and kappa light chain, as well as detection of the monoclonal rearrangement of the immunoglobulin heavy chain gene, helped to establish the diagnosis of lymphoma and to rule out an initially favored diagnosis of poorly differentiated carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / diagnosis*
  • Adrenal Gland Neoplasms / pathology
  • Aged
  • Antigens, CD20 / analysis
  • Cell Nucleolus / pathology
  • Cell Nucleus / pathology
  • Chromatin / pathology
  • Cytoplasm / pathology
  • Gene Rearrangement
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Immunoglobulin kappa-Chains / analysis
  • Immunohistochemistry
  • Keratins / analysis*
  • Leukocyte Common Antigens / analysis*
  • Lymphoma / diagnosis*
  • Lymphoma / pathology
  • Male
  • Tomography, X-Ray Computed

Substances

  • Antigens, CD20
  • Chromatin
  • Immunoglobulin Heavy Chains
  • Immunoglobulin kappa-Chains
  • Keratins
  • Leukocyte Common Antigens