Novel [1,2]- and [2,3]-Wittig rearrangements of alpha-benzyloxy beta-CF(3)-beta-lactam enolates

Org Lett. 2001 Aug 9;3(16):2529-31. doi: 10.1021/ol016198p.

Abstract

[reaction: see text] alpha-Benzyloxy alpha-CF(3)-beta-lactams are shown to offer the first examples of the enolate [1,2]- and enolate ortho-[2,3]-Wittig rearrangements which provide a unique entry to the alpha-benzyl-alpha-hydroxy lactams and the alpha-aryl-alpha-hydroxy lactams, respectively. Both products are potential precursors of new trifluoromethyl isoserines, and the latter is not accessible via the usual alkylation methodology.

MeSH terms

  • Alkylation
  • Indicators and Reagents
  • beta-Lactams / chemistry*

Substances

  • Indicators and Reagents
  • beta-Lactams