3-Aryl-2-oxazolidinones through the palladium-catalyzed N-arylation of 2-oxazolidinones

S Cacchi; G Fabrizi; A Goggiamani; G Zappia

doi:10.1021/ol016208m

3-Aryl-2-oxazolidinones through the palladium-catalyzed N-arylation of 2-oxazolidinones

Org Lett. 2001 Aug 9;3(16):2539-41. doi: 10.1021/ol016208m.

Authors

S Cacchi¹, G Fabrizi, A Goggiamani, G Zappia

Affiliation

¹ Dipartimento di Studi di Chimica e Tecnologia delle Sostanza Biologicamente Attive, Università degli Studi La Sapienza, P.le A. Moro 5, 00185 Rome, Italy. [email protected]

PMID: 11483055
DOI: 10.1021/ol016208m

Abstract

[reaction: see text] 3-Aryl-2-oxazolidinones are obtained in good yields through the palladium-catalyzed N-arylation of 2-oxazolidinones with aryl bromides. The nature of aryl bromides, phosphine ligands, bases, and solvents strongly affects the reaction outcome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Catalysis
Indicators and Reagents
Oxazoles / chemistry*
Palladium / chemistry*

Substances

Indicators and Reagents
Oxazoles
Palladium