Making the pain connection

Neuron. 2001 Jul 19;31(1):4-6. doi: 10.1016/s0896-6273(01)00352-x.

Abstract

Dorsal root ganglia (DRG) neurons include multiple types of sensory neurons with well-appreciated anatomical and physiological distinctions. In this issue of Neuron, Chen et al. adds to our molecular understanding of these differences by reporting that DRG11, a paired homeodomain transcription factor, is specifically required for the proper development of pain-sensing nociceptive neurons.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anterior Horn Cells / physiology
  • Ganglia, Spinal / physiology*
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism*
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins*
  • Neurons, Afferent / physiology*
  • Nociceptors / physiology*
  • Pain / physiopathology*
  • Spinal Cord / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • Prrxl1 protein, mouse
  • Transcription Factors