To identify the specific frontal and cingulate regions involved in response inhibition, five Chinese right-handed male volunteers with an attention span reaching or exceeding a 7-digit level participated in this blocked design functional magnetic resonance imaging study. Each block represented one of the two experimental conditions, the Correct Matching or the Incorrect Matching condition. In the Correct Matching condition, the subjects were required to make correct judgement of whether the two 3-digit numbers presented in succession were the same or not; whereas in the Incorrect Matching condition, the participants were instructed to inhibit the correct responses. Bilateral activations of the prefrontal and anterior cingulate as well as the left posterior cingulated cortex were observed while the subjects were exercising response inhibition. The roles of these activations in response inhibition were discussed.