Abstract
Two series of 3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones 2 with potential anti-inflammatory and analgesic activity were prepared and tested. Pharmacological results revealed that all the title compounds, endowed with an arylsulphonyl side chain, possess good antalgic activity and fair anti-inflammatory properties. The analgesic profile of the two series, evaluated by the acetic acid writhing test, showed that compounds 2c, 2f and 2h, in particular, were the most active. Structure-activity relationships are briefly discussed.
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / therapeutic use
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Disease Models, Animal
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Edema / drug therapy
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Female
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Male
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Mice
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Pain / drug therapy
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Rats
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Sulfur Compounds / chemical synthesis*
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Sulfur Compounds / chemistry
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
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Thiazoles / pharmacology
Substances
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Analgesics
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Anti-Inflammatory Agents
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Sulfur Compounds
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Thiazoles