Murine natural killer cell activation receptors

H R Smith; A H Idris; W M Yokoyama

doi:10.1034/j.1600-065x.2001.1810109.x

Murine natural killer cell activation receptors

Immunol Rev. 2001 Jun:181:115-25. doi: 10.1034/j.1600-065x.2001.1810109.x.

Authors

H R Smith¹, A H Idris, W M Yokoyama

Affiliation

¹ Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

PMID: 11513133
DOI: 10.1034/j.1600-065x.2001.1810109.x

Abstract

Natural killer (NK) cells express two types of receptors involved in target recognition: inhibitory receptors for target cell MHC class I molecules and activation receptors. While there has been significant progress in understanding the inhibitory receptors, less is known about the activation receptors. Detailed analysis of several mouse NK-cell activation receptors provides insight into the physiologic relevance of these receptors in the innate immune response.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Antigens, Ly*
Gene Expression
Humans
Killer Cells, Natural / immunology*
Lectins, C-Type
Membrane Glycoproteins / genetics
Membrane Glycoproteins / metabolism
Mice
Receptors, Immunologic / genetics
Receptors, Immunologic / metabolism*
Receptors, NK Cell Lectin-Like
Species Specificity

Substances

Antigens, Ly
Lectins, C-Type
Membrane Glycoproteins
Receptors, Immunologic
Receptors, NK Cell Lectin-Like